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KMID : 0620920180500080099
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Experimental & Molecular Medicine
2018 Volume.50 No. 8 p.99 ~ p.99
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Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice
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Choi Yun-Sik
Lee Sang-Hyuk
Kim Kap-Youl
Kim Soo-Hyun
Chung Yeun-Jun
Lee Charles
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Abstract
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Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient’s own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.
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KEYWORD
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Cancer immunotherapy, Cancer models
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